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KMID : 0357919800140010047
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Korean Journal of Pathology
1980 Volume.14 No. 1 p.47 ~ p.53
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Histological Distinction between Primary Lymphoma and Leukemic Infiltration of Lymph nodes
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Abstract
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The pathologist faced with the necessity for examining the lymph node biopsy needs
certain criteria for the differentiation between primary malignant lymphoma and
secondary leukemic infiltration into the lymph node. The distinction is not only of
academic interest but also has a practical importance because the management of patient
with these two diseases is different.
Authors conducted a morphological study on 24 lymph nodes that were diagnosed
either as lymphnode involvement by lymphogenous leukemia (Group I ). malignant
lymphoma of poorly differentiated lymphocytic type (Group II ) or These lymph node
specimens were obtained during a period of 10 years from January 1970 to December
1979 at the Department of Pathology of Seoul National University Hospital. The
distinction between two groups was made by clinical and hematological findings. To
evaluate these Iymph nodes ten items were set beforehand, and the results were
tabulated (Table I).
In summary there was not a single histological feature that would distinguish these
two groups of disease. However, combining the various features listed in table I we
could reasonably besure of differentiating one from the other. Reviewing the useful
histological findings, paucity of mitosis, monotonous tumor cell population in lymph node
with involvement of intranodal veins and infiltrating features suggestive of Indian file,
were particularly prominent in leukemic infiltration of lymph nodes as compared to
lymph nodes involved by primary malignant lymphoma.
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KEYWORD
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